منابع مشابه
Water and cellular folding processes.
Proteins require a unique, native structure to perform their functions. Water molecules play an important role to develop and maintain this three-dimensional structure. Water is also necessary for several forms of enzyme catalysis, and is a constituent of many protein-protein, protein-DNA, or protein-RNA interfaces. Larger proteins acquire their native structure in a complicated folding pathway...
متن کاملCellular pathways controlling integron cassette site folding.
By mobilizing small DNA units, integrons have a major function in the dissemination of antibiotic resistance among bacteria. The acquisition of gene cassettes occurs by recombination between the attI and attC sites catalysed by the IntI1 integron integrase. These recombination reactions use an unconventional mechanism involving a folded single-stranded attC site. We show that cellular bacterial...
متن کاملMolecular chaperones--cellular machines for protein folding.
Proteins are linear polymers synthesized by ribosomes from activated amino acids. The product of this biosynthetic process is a polypeptide chain, which has to adopt the unique three-dimensional structure required for its function in the cell. In 1972, Christian Anfinsen was awarded the Nobel Prize for Chemistry for showing that this folding process is autonomous in that it does not require any...
متن کاملCellular folding pathway of a metastable serpin.
Although proteins generally fold to their thermodynamically most stable state, some metastable proteins populate higher free energy states. Conformational changes from metastable higher free energy states to lower free energy states with greater stability can then generate the work required to perform physiologically important functions. However, how metastable proteins fold to these higher fre...
متن کاملCellular Evolutionary Algorithms for Solving Protein Folding Problem
Proteins are vital components of living cells. A number of diseases such as Alzheimer's, Cystic fibrosis and Mad Cow diseases are shown to result from malfunctioning of proteins. Protein folding problem is the process of predicting the optimal 3D molecular structure of a protein, or tertiary structure, which is an indication of its proper function. An enhancement over Cellular Genetic Algorithm...
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ژورنال
عنوان ژورنال: Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics
سال: 1998
ISSN: 1303-5991
DOI: 10.1501/commua1_0000000417